Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis. (9th November 2021)

• Record Type: Journal Article
• Authors: Patel, Miten; Savvopoulos, Fotios; Berggren, Caleb C.; Aslanidou, Lydia; Timmins, Lucas H.; de Silva, Ranil; Pedrigi, Ryan M.; Krams, Rob
• Is Part Of: Journal of biomechanics. Volume 128(2021)
• Publication Date: 2021-11-09
• Subjects: Murine carotid artery -- Atherosclerotic plaques -- Wall shear stress -- Endothelial strain -- Mechanical modelling -- Fluid-structure interaction -- Computational fluid dynamics -- Residual stress -- Backward incremental method; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2021.110720
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed shear stress profiles. However, in addition to shear stress, endothelial cells also experience artery wall strain that could contribute to atherosclerosis progression. Herein, we describe a method to accurately obtain these shear stress and strain profiles. We developed a fluid–structure interaction (FSI) framework for modelling arteries within a commercially available package (Abaqus, version 6.14) that included known prestresses (circumferential, axial and pressure associated). In addition, we co-registered 3D histology to a micro-CT-derived 3D reconstruction of an atherosclerotic carotid artery from a cholesterol-fed ApoE −/− mouse to include the spatial distribution of lipids within a subject-specific model. The FSI model also incorporated a nonlinear hyperelastic material model with regionally-varying properties that distinguished between healthy vessel wall and plaque. FSI predicted a lower shear stress than CFD (~−12%), but further decreases in plaque regions with softer properties (~-24%) were dependent on the approach used to implement the prestresses in the artery wall. When implemented with our new hybrid approach (zero prestresses in regions of lipid deposition), there was significant heterogeneity in endothelial shear stress in the atherosclerotic artery due to variations in stiffness and, in turn, wall strain. In conclusion, when obtaining endothelial shear stress and strain in diseased arteries, a careful consideration of prestresses is necessary. This paper offers a way to implement them.