A self-healing carboxymethyl chitosan/oxidized carboxymethyl cellulose hydrogel with fluorescent bioprobes for glucose detection. (15th November 2021)

• Record Type: Journal Article
• Authors: Shen, Yuhan; Wang, Zhaoliang; Wang, Yongchao; Meng, Zhiyuan; Zhao, Zheng
• Is Part Of: Carbohydrate polymers. Volume 274(2021)
• Publication Date: 2021-11-15
• Subjects: Biosensors -- Fluorescent sensing -- AuNCs -- Self-healing hydrogels -- Glucose; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118642
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Self-healing hydrogel as a soft material with high durability and life-time has been successfully applied in various fields, including electronic skins, wearable electronic devices, and soft sensors. However, it is still a challenge to design a hydrogel with rapid self-healing, biodegradable and biosensing properties. Here, a self-healing carboxymethyl chitosan (CMCS)/oxidized carboxymethyl cellulose (OCMC) hydrogel with fluorescent bioprobes was developed for glucose detection. In this biosensing system, gold nanoclusters (AuNCs) and glucose oxidase (GOx) were encapsulated into the CMCS/OCMC hydrogel matrix as the fluorescent bioprobes. The CMCS/OCMC hydrogel with fluorescent bioprobes exhibited high sensitivity for glucose sensing with a linearly detection range of 100 μM to 5 mM and a detection limit of 0.029 mM, which covered the level of glucose in clinical detection. Furthermore, this hydrogel exhibited good biocompatibility. Finally, In vitro blood fluorescence tests and in vivo fluorescence investigation of the AuNCs-CMCS/OCMC hydrogel in diabetic mice indicated that this biocompatible and self-healing hydrogel based on fluorescent sensing system had potential application in implantable biosensing area for glucose monitoring. Highlights: The hydrogel shows excellent material exchange ability and self-healing property. The biosensor has high sensitivity to hydrogen peroxide and glucose, can clearly distinguish them according to the phenomenon. The test method is simple and quick, the cost is low. The hydrogel has good biocompatibility and has a prospect of clinical application.