Mapping of N−C Bond Formation from a Series of Crystalline Peri‐Substituted Naphthalenes by Charge Density and Solid‐State NMR Methodologies. Issue 44 (1st October 2021)

• Record Type: Journal Article
• Authors: Rees, Gregory J.; Pitak, Mateusz B.; Lari, Alberth; Day, Stephen P.; Yates, Jonathan R.; Gierth, Peter; Barnsley, Kristian; Smith, Mark E.; Coles, Simon J.; Hanna, John V.; Wallis, John D.
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 44(2021)
• Page Start: 23878
• Page End: 23884
• Publication Date: 2021-10-01
• Subjects: bond theory -- NMR spectroscopy -- through-bond interaction -- through-space interaction -- X-ray diffraction; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202111100
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A combination of charge density studies and solid state nuclear magnetic resonance (NMR) 1 J NC coupling measurements supported by periodic density functional theory (DFT) calculations is used to characterise the transition from an n–π* interaction to bond formation between a nucleophilic nitrogen atom and an electrophilic sp 2 carbon atom in a series of crystalline peri‐substituted naphthalenes. As the N⋅⋅⋅C distance reduces there is a sharp decrease in the Laplacian derived from increasing charge density between the two groups at ca. N⋅⋅⋅C = 1.8 Å, with the periodic DFT calculations predicting, and heteronuclear spin‐echo NMR measurements confirming, the 1 J NC couplings of ≈3–6 Hz for long C−N bonds (1.60–1.65 Å), and 1 J NC couplings of <1 Hz for N⋅⋅⋅C >2.1 Å. Abstract : A combination of charge density measurements, solid‐state NMR 1 J NC couplings, and DFT calculations is presented to characterise the transition from an n–π* interaction to bond formation for a series of model crystalline peri‐substituted naphthalenes.