Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment. (26th November 2021)

• Record Type: Journal Article
• Authors: Spósito, Larissa; Fortunato, Giovanna Capaldi; de Camargo, Bruna Almeida Furquim; Ramos, Matheus Aparecido dos Santos; Souza, Maurício Palmeira Chaves de; Meneguin, Andréia Bagliotti; Bauab, Taís Maria; Chorilli, Marlus
• Is Part Of: Journal of drug targeting. Volume 29:Number 10(2021)
• Page Start: 1029
• Page End: 1047
• Publication Date: 2021-11-26
• Subjects: Peptic ulcer disease -- drug delivery system -- Helicobacter pylori -- non-steroidal anti-inflammatory drugs -- microparticles -- nanoparticles -- microemulsion; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.1080/1061186X.2021.1904249
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Peptic ulcer disease (PUD) is a common condition that is induced by acid and pepsin causing lesions in the mucosa of the duodenum and stomach. The pathogenesis of PUD is a many-sided scenario, which involves an imbalance between protective factors, such as prostaglandins, blood flow, and cell renewal, and aggressive ones, like alcohol abuse, smoking, Helicobacter pylori colonisation, and the use of non-steroidal anti-inflammatory drugs. The standard oral treatment is well established; however, several problems can decrease the success of this therapy, such as drug degradation in the gastric environment, low oral bioavailability, and lack of vectorisation to the target site. In this way, the use of strategies to improve the effectiveness of these conventional drugs becomes interesting. Currently, the use of drug delivery systems is being explored as an option to improve the drug therapy limitations, such as antimicrobial resistance, low bioavailability, molecule degradation in an acid environment, and low concentration of the drug at the site of action. This article provides a review of oral drug delivery systems looking for improving the treatment of PUD.