Capsulactone: a new 4-hydroxy-α-pyrone derivative from an endophytic fungus Penicillium capsulatum and its antimicrobial activity. Issue 11 (15th November 2021)

• Record Type: Journal Article
• Authors: Xian, Peng-Jie; Chen, Heng-Ye; Feng, Zhang; Zhao, Wei; Yang, Xiao-Long
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 11(2021)
• Page Start: 1100
• Page End: 1106
• Publication Date: 2021-11-15
• Subjects: Panax notoginseng -- Penicillium capsulatum -- pyrone -- capsulactone -- antimicrobial activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1847092
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new 4-hydroxy-α-pyrone, namely capsulactone (1), was isolated from an endophytic fungus Penicillium capsulatum XL027 obtained from the leaves of Panax notoginseng . The structure and absolute configuration of 1 were elucidated through a combination of spectroscopic data and computed methods, as well as by comparison with literature data. Compound 1 exhibited weak activity against methicinllin-resistant Staphylococcus aureus with an MIC value of 100 μg/ml. Graphical Abstract: UF0001