Effects of Different Rest Period Durations Prior to Blood Pressure Measurement: The Best Rest Trial. Issue 5 (4th October 2021)

• Record Type: Journal Article
• Authors: Brady, Tammy M.; Charleston, Jeanne; Ishigami, Junichi; Miller, Edgar R.; Matsushita, Kunihiro; Appel, Lawrence J.
• Is Part Of: Hypertension. Volume 78:Issue 5(2021)
• Page Start: 1511
• Page End: 1519
• Publication Date: 2021-10-04
• Subjects: blood pressure -- cardiovascular disease -- clinical trial -- hypertension -- prevention screening; Hypertension -- Periodicals; Hypertension -- Treatment -- Periodicals; 616.132005
• DOI: 10.1161/HYPERTENSIONAHA.121.17496
• Languages: English
• ISSNs: 0194-911X

Abstract

Abstract : Supplemental Digital Content is available in the text. Abstract : A rest period of 3 to 5 minutes before blood pressure (BP) measurement is recommended in hypertension guidelines but can be challenging to implement. We conducted a randomized trial to determine the effects of resting for <5 minutes on BP. In a cross-over design, 113 participants (mean age 55 years, 36% male, 75% Black) had 4 sets of triplicate BP measurements with the order of rest for the first 3 sets (0 minutes, 2 minutes, 5 minutes1 ) randomized. The fourth set was always a second 5-minute rest period (5 minutes2 ), from which we calculated the difference between 5 minutes1 and 5 minutes2 (5 minutes1 −5 minutes2 ), a measure of intrinsic BP variability. To determine if there was no difference between BPs obtained after resting 0 minutes or 2 minutes versus 5 minutes1, we tested whether 5 minutes1 −0 minutes or 5 minutes1 −2 minutes was within a prespecified noninferiority margin of ±2 mm Hg compared with 5 minutes1 −5 minutes2 . Overall, mean BP was similar across 5 minutes1 (128/75), 5 minutes2 (127/76), 2 minutes (127/74), and 0 minutes (127/74). Compared with the average absolute 5 minutes1 −5 minutes2 difference (5.3/3.0 mm Hg), the absolute systolic BP difference of differences did not cross our noninferiority margin for 0 minutes rest (0.2 [95% CI, 0.8–1.2]) but did for 2 minutes rest (−1.7 [−2.8 to −0.6]). Among those with systolic BP <140, the absolute difference of differences for both 0 and 2 minutes did not cross the ±2 mm Hg margin; however, those with systolic BP ≥140 had differences that did exceed this threshold. Our findings suggest that shorter rest periods may be a reasonable alternative to 5 minutes for most individuals. Implementation could substantially improve the efficiency of hypertension screening programs. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04031768.