Evaluation of developmental and transcriptional effects of α-mangostin on zebrafish embryos. Issue 3 (16th March 2021)

• Record Type: Journal Article
• Authors: Kitipaspallop, Wannakarn; Sillapaprayoon, Siwapech; Taepavarapruk, Pornnarin; Chanchao, Chanpen; Pimtong, Wittaya
• Is Part Of: Toxicological and environmental chemistry. Volume 103:Issue 3(2021)
• Page Start: 254
• Page End: 268
• Publication Date: 2021-03-16
• Subjects: α-Mangostin -- xanthone -- zebrafish -- developmental toxicity -- transcriptional effect; Toxicology -- Periodicals; Environmental chemistry -- Periodicals; 571.95
• DOI: 10.1080/02772248.2021.1960349
• Languages: English
• ISSNs: 0277-2248

Abstract

Abstract: α-Mangostin is a primary active compound found in mangosteen pericarp that has been used as a traditional medicine in Thailand and other countries in Southeast Asia. Since toxicological information is limited, developmental toxicity and transcriptional effects of α-mangostin during embryogenesis of zebrafish were studied. Zebrafish embryos were exposed to α-mangostin (up to 15 µmol/L) from 4 hours up to 72 the 50% lethal concentration was estimated as 6.9 ± 1.9 µmol/L. The compound induced developmental defects in zebrafish embryos/larvae, mainly consisting of truncated bodies, bent tails, blood clots, and pericardial and yolk edemas. α-Mangostin increased malformation in body shape and tail morphology. Additionally, the compound altered the transcriptional expression levels of genes correlated with oxidative stress, inflammation, apoptosis, and hematopoiesis. Further research will be necessary to evaluate if α-mangostin may cause developmental toxicity in other animals.