Recommendations for pregnancy in Fanconi anemia. (2nd November 2021)

• Record Type: Journal Article
• Authors: Matar, Charbel F.; Bou-Fakhredin, Rayan; Russo, Roberta; Andolfo, Immacolata; Iolascon, Achille; Taher, Ali T.
• Is Part Of: Expert opinion on biological therapy. Volume 21:Number 11(2021)
• Page Start: 1403
• Page End: 1409
• Publication Date: 2021-11-02
• Subjects: Pregnancy -- Fanconi anemia -- maternal outcome -- delivery -- bone marrow transplantation -- fetal outcome; Gene therapy -- Periodicals; Protein drugs -- Periodicals; Peptide drugs -- Periodicals; Immunotherapy -- Periodicals; Drug delivery systems -- Periodicals; 615.5
• DOI: 10.1080/14712598.2021.1913119
• Languages: English
• ISSNs: 1471-2598

Abstract

ABSTRACT: Introduction : Fanconi anemia (FA) is a rare congenital disease that belongs to the family of congenital trilinear bone marrow failure. Most FA patients will suffer bone marrow failure and the main treatment relies on supportive measures or more recently on the use of hematopoietic stem cell transplant. The improvements seen in the management of FA has led women to reach childbearing age and have successful pregnancies. However, these pregnancies are associated with increased complications such as preterm delivery, cesarean delivery, eclampsia and others. Areas covered : This review highlights on the outcome of pregnancies in FA patients reported in the literature along with practical recommendations. Expert opinion : Multidisciplinary efforts are required to optimize the management of pregnancy in FA patients. Moreover, the development of a set of recommendations to optimize the treatment is highly necessary.