Extraskeletal Myxoid Chondrosarcoma of the Vulva Confirmed by EWSR1 FISH: A Case Report and Review of the Literature. (16th September 2021)

• Record Type: Journal Article
• Authors: Salah, Haneen T.; Stivers, Nicole S.; Jarboe, Elke A.; Dodson, Mark K.; Ward, Michael B.
• Is Part Of: International journal of gynecological pathology. Volume 40:Number 5(2021)
• Page Start: 470
• Page End: 476
• Publication Date: 2021-09-16
• Subjects: Extraskeletal myxoid chondrosarcoma -- Vulva -- Sarcoma -- EWSR1; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000723
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Extraskeletal myxoid chondrosarcoma of the vulva is a very rare tumor, with less than 10 cases reported in the literature. We report a case of a 45-yr-old woman with extraskeletal myxoid chondrosarcoma of the vulva confirmed by EWSR1 fluorescence in situ hybridization. Given the unusual site and prominent myxoid morphology, a broad differential diagnosis and a variety of ancillary testing was required. This article aims to review extraskeletal myxoid chondrosarcoma of the vulva, the differential diagnosis of a myxoid spindle cell neoplasm of the vulva, and the diagnostic importance of immunohistochemistry and EWSR1 fluorescence in situ hybridization.