Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report. (25th September 2021)

• Record Type: Journal Article
• Authors: Catteau, Xavier; Preat, Fanny; D'haene, Nicky; Noël, Jean-Christophe
• Is Part Of: International journal of gynecological pathology. Volume 40:Number 5(2021)
• Page Start: 448
• Page End: 451
• Publication Date: 2021-09-25
• Subjects: Low grade -- Serous carcinoma -- BRAF -- Osseous -- Metaplasia; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000732
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : A 44-yr-old woman presented with lower, painless abdominal discomfort and a vacuolated mass measuring 12 cm on the right-hand side of the pelvis. She subsequently underwent a bilateral salpingo-oophorectomy. An osseous lesion was identified in the left ovary, which was hard in consistency and was associated with a multicystic complex lesion. Microscopic examination of the left ovary showed clusters of serous cells with moderate atypia, surrounded by a desmoplastic stroma with large areas of bone matrix. To the best of our knowledge, this is the first reported case of low-grade serous carcinoma with osseous metaplasia and a BRAF mutation.