Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant: Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia. Issue 9 (19th July 2021)

• Record Type: Journal Article
• Authors: Ruhayel, Sandra D.; Foley, David A.; Hamilton, Kate; Ferguson, Patricia; Kotecha, Rishi S.; Bowen, Asha C.; Yeoh, Daniel K.
• Is Part Of: Pediatric infectious disease journal. Volume 40:Issue 9(2021)
• Page Start: 832
• Page End: 834
• Publication Date: 2021-07-19
• Subjects: viridans group streptococci -- vancomycin -- febrile neutropenia -- leukemia -- hematopoietic stem cell transplant; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003210
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Supplemental Digital Content is available in the text. Abstract : Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.