Checkpoint Inhibitor-associated Cutaneous Small Vessel Vasculitis: A Review of the Literature. Issue 3 (14th April 2021)

• Record Type: Journal Article
• Authors: Ho, Bernard; Larkin, James; Heelan, Kara
• Is Part Of: Journal of immunotherapy. Volume 44:Issue 3(2021)
• Page Start: 118
• Page End: 121
• Publication Date: 2021-04-14
• Subjects: immune-related adverse events -- checkpoint inhibitors -- vasculitis; Immunotherapy -- Periodicals; Immunotherapy -- Periodicals; Neoplasms -- therapy -- Periodicals; Electronic journals; Electronic journals; 615.37
• DOI: 10.1097/CJI.0000000000000352
• Languages: English
• ISSNs: 1524-9557

Abstract

Abstract : Checkpoint inhibitor therapy is an established cancer treatment option often complicated by the development of immune-related adverse events. Vasculitis has been reported with a broad spectrum of both cutaneous and systemic manifestations and can be complicated by delayed diagnosis. The authors report 2 histologically proven cases of cutaneous leucocytoclastic vasculitis induced by programmed cell-death 1 inhibitor inhibitor nivolumab. As physicians, including medical oncologists and dermatologists, we need to be aware of this clinical entity and the importance of clinicopathological confirmation in this setting to confirm the diagnosis to help guide the management of these complex patients.