One-pot solvent-free extraction and formulation of lipophilic natural products: from curcuma to dried formulations of curcumin. Issue 22 (8th September 2021)

• Record Type: Journal Article
• Authors: Dall'armellina, Alice; Letan, Mathias; Duval, Charles; Contino-Pépin, Christiane
• Is Part Of: Green chemistry. Volume 23:Issue 22(2021)
• Page Start: 8891
• Page End: 8900
• Publication Date: 2021-09-08
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc00587a
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A novel dual green extraction and encapsulation of liposoluble natural products is proposed and successfully applied to curcumin. Abstract : A new environmentally friendly process for the efficient extraction and formulation of lipophilic bioactive compounds from plants has been successfully developed. This study describes the application of this ultrasound-assisted technique to the simultaneous encapsulation and extraction of curcumin from Curcuma longa in a medium essentially composed of water with the addition of biocompatible oil and surfactant. The resulting curcuminoid-loaded emulsion was called "extremulsion" for extract-emulsion. The composition of the extractant medium and ultrasonic parameters were studied to obtain optimal extremulsions in terms of droplet size, stability and curcumin-loading. Extremulsions comprising droplets with a diameter on the order of 100 nm were obtained with a curcumin recovery rate up to 87% compared to the conventional Soxhlet-assisted extraction in acetone. Their stability during the freeze-drying step has been studied in order to obtain a curcumin-loaded formulation easily stored and ready for use. Extremulsions did not show significant alteration in droplet size and composition after freeze-drying and rehydration.