Electro-oxidative C–H amination of heteroarenes with aniline derivatives via radical–radical cross coupling. Issue 22 (25th October 2021)

• Record Type: Journal Article
• Authors: Peng, Xichao; Zhao, Junhao; Ma, Guojian; Wu, Yan; Hu, Shiyu; Ruan, Zhixiong; Feng, Pengju
• Is Part Of: Green chemistry. Volume 23:Issue 22(2021)
• Page Start: 8853
• Page End: 8858
• Publication Date: 2021-10-25
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc02821a
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A protocol for the C–H amination of heteroarenes via an electro-oxidative radical cross coupling process could access variety of hetero-arene derivatives and tolerate a wide range of functional groups, and is amenable to the gram scale synthesis. Abstract : The selective synthesis of C-2/C-3 aminated five-membered heteroarenes incorporated various functionalities with aniline derivatives in a sustainable way remains an unmet challenge. This protocol presents a practical protocol for the C–H amination of heteroarenes via an electro-oxidative cross coupling process. This electrosynthetic approach enables a facile access to a wide variety of synthetically useful hetero-arene derivatives, tolerates a wide range of functional groups, and is amenable to gram scale synthesis. In addition, a preliminary mechanistic study reveals that a radical cross coupling process between the N-centered radical and indole radical cation may be involved for this amination reaction.