Carbon dots up-regulate heme oxygenase-1 expression towards acute lung injury therapy. Issue 43 (7th October 2021)

• Record Type: Journal Article
• Authors: Wang, Bo; Liu, Peipei; Huang, Hui; Wang, Xiting; Zhang, Mengling; Huang, Jian; Lu, Fang; Chen, Jian; Liu, Yang; Kang, Zhenhui
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 43(2021)
• Page Start: 9005
• Page End: 9011
• Publication Date: 2021-10-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb01283e
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Carbon dots up-regulate heme oxygenase-1 expression towards the acute lung injury therapy. Abstract : Pneumonia is a kind of inflammation, which can cause high morbidity and mortality, and the treatment of pneumonia has received widespread attention. Heme oxygenase-1 (HMOX1) is a cell protective enzyme and can generate an anti-inflammatory response. Here, we demonstrate that degradable carbon dots (from l -ascorbic acid, CDs-1) can up-regulate the expression of HMOX1 in animal cells and tissues, which has a therapeutic effect on LPS-induced acute lung injury in mice. It was confirmed from in vitro experiments that CDs-1 could significantly up-regulate the expression of mRNA and the protein of HMOX1, which can increase the expression of HMOX1 by 5 times in a short time, decreasing the reactive oxygen species level in a cellular inflammation model induced by LPS. Furthermore, a series of in vivo comparative experiments show that CDs-1 could effectively treat acute lung injury and improve the survival rate of mice to 80%. Our work provides a practical way for the treatment of acute inflammation and the promising application of CDs in anti-inflammation.