Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S8. (2nd March 2021)

• Record Type: Journal Article
• Authors: Jiménez, Sònia; Miró, Òscar; Llorens, Pere; Martín-Sánchez, Francisco J.; Burillo-Putze, Guillermo; Piñera, Pascual; Martín, Alfonso; Alquézar, Aitor; García-Lamberechts, Eric J.; Jacob, Javier; Grima, María L.L.; Millán, Javier; Molina, Francisca; Albero, Patricia B.; Cardozo, Carlos; Mòdol, Josep M.; Aguirre, Alfons; Gaya, Ruth; Adroher, María; Llauger, Lluís; Díaz, Juan J. L.; González, Nayra C.; Aragües, Paula L.; Gómez, Ana P.; del Castillo, Juan G.
• Other Names: other.
• Is Part Of: European journal of emergency medicine. Volume 28:Number 3(2021)
• Page Start: 218
• Page End: 226
• Publication Date: 2021-03-02
• Subjects: clinical characteristics -- coronavirus disease 2019 -- deep venous thrombosis -- incidence -- outcome -- risk factors -- severe acute respiratory syndrome coronavirus 2; Emergency medicine -- Europe -- Periodicals; Medical emergencies -- Europe -- Periodicals; Emergency medical services -- Europe -- Periodicals; Emergencies -- Europe -- Periodicals; Emergency Medical Services -- Europe -- Periodicals; Emergency Medicine -- Europe -- periodicals; 616.025
• DOI: 10.1097/MEJ.0000000000000783
• Languages: English
• ISSNs: 0969-9546

Abstract

Abstract : Background and importance: A higher incidence of venous thromboembolism [both pulmonary embolism and deep vein thrombosis (DVT)] in patients with coronavirus disease 2019 (COVID-19) has been described. But little is known about the true frequency of DVT in patients who attend emergency department (ED) and are diagnosed with COVID-19. Objective: We investigated the incidence, risk factors, clinical characteristics and outcomes of DVT in patients with COVID-19 attending the ED before hospitalization. Methods: We retrospectively reviewed all COVID patients diagnosed with DVT in 62 Spanish EDs (20% of Spanish EDs, case group) during the first 2 months of the COVID-19 outbreak. We compared DVT-COVID-19 patients with COVID-19 without DVT patients (control group). Relative frequencies of DVT were estimated in COVID and non-COVID patients visiting the ED and annual standardized incidences were estimated for both populations. Sixty-three patient characteristics and four outcomes were compared between cases and controls. Results: We identified 112 DVT in 74 814 patients with COVID-19 attending the ED [1.50‰; 95% confidence interval (CI), 1.23–1.80‰]. This relative frequency was similar than that observed in non-COVID patients [2109/1 388 879; 1.52‰; 95% CI, 1.45–1.69‰; odds ratio (OR) = 0.98 [0.82-1.19]. Standardized incidence of DVT was higher in COVID patients (98, 38 versus 42, 93/100, 000/year; OR, 2.20; 95% CI, 2.03–2.38). In COVID patients, the clinical characteristics associated with a higher risk of presenting DVT were older age and having a history of venous thromboembolism, recent surgery/immobilization and hypertension; chest pain and desaturation at ED arrival and some analytical disturbances were also more frequently seen, d-dimer >5000 ng/mL being the strongest. After adjustment for age and sex, hospitalization, ICU admission and prolonged hospitalization were more frequent in cases than controls, whereas mortality was similar (OR, 1.37; 95% CI, 0.77–2.45). Conclusions: DVT was an unusual form of COVID presentation in COVID patients but was associated with a worse prognosis.