Leucomethylene blue probe detects a broad spectrum of reactive oxygen and nitrogen species. Issue 51 (29th September 2021)

• Record Type: Journal Article
• Authors: Cremer, Christopher; Merkes, Jean Michél; Bub, Christina L.; Rommel, Dirk; Patureau, Frederic W.; Banala, Srinivas
• Is Part Of: RSC advances. Volume 11:Issue 51(2021)
• Page Start: 32295
• Page End: 32299
• Publication Date: 2021-09-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra06498c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A broad spectrum ROS/RNS sensing butylated phenol tethered leucomethylene blue is presented. This probe detects a variety of ROS/RNS, with up to 100-fold gain in fluorescence in the red range, is suitable for microscopic and macroscopic in vivo fluorescence imaging. Abstract : Reactive oxygen and nitrogen species (ROS, RNS) are ubiquitous in biology with a variety of physiological and pathological functions. Here we describe a broad spectrum ROS/RNS detecting fluorogenic probe with red fluorescence emission and up to 100-fold gain. Hence these modified probes are useful for in vivo non-invasive quantification of ROS/RNS.