COVID-19: gastrointestinal symptoms from the view of gut–lung axis. Issue 5 (29th October 2020)

• Record Type: Journal Article
• Authors: Zhang, Mengna; Zhou, Yunjiao; Li, Haiou; Peng, Yanan; Qiu, Peishan; Shi, Xianyan; Pan, Xingfei; Liu, Jing
• Is Part Of: European journal of gastroenterology & hepatology. Volume 33:Issue 5(2021)
• Page Start: 610
• Page End: 612
• Publication Date: 2020-10-29
• Subjects: coronavirus disease 2019 -- gastrointestinal symptoms -- gut -- lung axis; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000001984
• Languages: English
• ISSNs: 0954-691X

Abstract

Abstract : The main symptoms of coronavirus disease 2019 (COVID-19) are respiratory manifestations, while some confirmed patients developed gastrointestinal symptoms or even initially presented digestive symptoms. The link between pneumonia and gastrointestinal symptoms caused by severe acute respiratory symptoms coronavirus 2 focused our attention on the concept of 'gut–lung axis'. In this review, we discuss the inevitability and possible mechanisms of the occurrence of intestinal symptoms or intestinal dysfunction in COVID-19 from the perspective of the gut–lung axis, as well as the influence of the imbalance of intestinal homeostasis on the respiratory symptoms of COVID-19. The interaction between lung and intestine might lead to a vicious cycle of pulmonary and intestinal inflammation which may be a potential factor leading to the death of patients with COVID-19.