A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function. Issue 4 (October 2021)

• Record Type: Journal Article
• Authors: Degens, Hans; Swaminathan, Anandini; Tallis, Jason
• Is Part Of: Exercise and sport sciences reviews. Volume 49:Issue 4(2021)
• Page Start: 253
• Page End: 259
• Publication Date: 2021-10
• Subjects: aging -- muscle -- methionine restriction -- high-fat diet -- lipotoxicity -- muscle function -- obesity; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000261
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : The negative effects of a high-fat diet on skeletal muscle structure and function occur earlier in old age. Abstract : The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.