The Effect of Morbid Obesity or Advanced Maternal Age on Oxytocin-induced Myometrial Contractions: An In Vitro Study. Issue 2 (24th June 2021)

• Record Type: Journal Article
• Authors: Luca, A.M.; Carvalho, J.C.A.; Ramachandran, N.; Balki, M.
• Is Part Of: Obstetric anesthesia digest. Volume 41:Issue 2(2021)
• Page Start: 88
• Page End: 89
• Publication Date: 2021-06-24
• Subjects: Pharmacology -- Maternal Obesity; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000744168.98416.60
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( Can J Anesth . 2020;67:836–846) Worldwide, the rate of pregnant women who are of advanced maternal age (AMA) or who are overweight or morbidly obese is rising. These factors are associated with higher rates of labor induction or augmentation, prolonged labor, cesarean delivery and postpartum hemorrhage (PPH). Oxytocin is used both to prevent and treat PPH and for labor induction and augmentation. However, when oxytocin use is prolonged, a phenomenon known as oxytocin receptor desensitization can occur. This desensitization weakens the contractile response to repeated oxytocin treatment and can lead to severe PPH. The aim of this study was to investigate in vitro the effect of oxytocin on myometrial contractions in pregnant women with AMA and morbid obesity.