130 Prognostic significance of lymphovascular space invasion in epithelial ovarian cancer. (13th November 2020)

• Record Type: Journal Article
• Authors: Mansouri, H; Zemni, I; Jaidane, O; Ben Safta, I; Ben Hassouna, J; Hechiche, M; Chargui, R; Ben Rahal, K
• Is Part Of: International journal of gynecological cancer. Volume 30(2020)Supplement 3
• Page Start: A58
• Page End: A58
• Publication Date: 2020-11-13
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2020-IGCS.111
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: To identify the clinical, therapeutic and survival impact of lymphovascular space invasion (LVSI) in epithelial ovarian cancer. Methods: Retrospective study of 151 patients staged surgically in Salah Azaiez Tunisian cancer center, between 2000 and 2010. Results: We performed primary debulking surgery in 128 patients (84.8%) and 23 patients (15.2%) underwent and interval debulking surgery. Maximal cytoreduction (R0) was achieved in 67 of patients (44.4%), 39 patients had a residual disease ≤1 cm (25.8%) and 45 patients had a residual disease >1 cm (28.8%). LVSI were recorded in 51 patients (33.8%).LVSI was were associated to higher serum level of CA 125 >1000UI/ml (52.9% vs 33%, p=0.01), higher quantity of ascites >1litre (49% vs 28%, p=0.01) with more frequent cacinomatosis in the upper abdomen (60.8% vs 31%, p<0.0001) and more residual disease R1/R2 (72.5% vs 47%, p<0.0001), bilateral tumors (82.4% vs 58%, p=0.003), advanced FIGO stage III-IV (96.1% vs 68%, p<0.0001) and high tumor grade (88.3% vs 59%, p<0.0001). Among the 84 patients who underwent lymphadenectomy, LVSI positive tumors were correlated to higher risk of lymph node metastasis (LNM) (57.1% vs 30.4%, p=0.018) with higher LN ratio (13.95±21.69 vs 7.25±17.90, p=0.17) and more frequent associated pelvic and para aortic LNM (33.3% vs 10.2%, p=0.015). LVSI positive tumors were correlated to a decreased 5-years overall survival (25.2%vs 44%, p=0.004) and recurrence free survival (26.8% vs 47%, p=0.019). Conclusion: LVSI is an independent predictor of extended lymph node metastasis, progression and survival in patients with primary epithelial ovarian cancer.