319 High tumor-stroma ratio in estrogen receptor-positive breast cancer is correlated to poor histopathological parameters. (13th November 2020)

• Record Type: Journal Article
• Authors: Bacha, D; Ben Amor, A; Halouani, A; Lahmar, A; Ben Slama, S
• Is Part Of: International journal of gynecological cancer. Volume 30(2020)Supplement 3
• Page Start: A128
• Page End: A128
• Publication Date: 2020-11-13
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2020-IGCS.273
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction: In breast cancer, attention has focused on the prognostic value of tumor- stroma ratio (TSR), mainly in the triple-negative subtype, which generally has a poor prognosis. Little prognostic data are available for other carcinoma types. Objective: To determine the prognostic value of TSR in estrogen receptor (ER) positive invasive breast carcinomas. Methods: TSR was measured in hematoxylin and eosin-stained surgical specimens of 70 consecutive EP positive breast carcinomas. Tissue from the most invasive part of the tumor was used. A part of the sample was selected where both tumor and stromal tissue were available. Scoring percentages were given per 10-fold per image field. Tumors with a low ratio had ≥50% of stroma and a high ratio had <50% of stroma. The relationship of TSR to routinely used prognostic histopathological parameters (tumor size, grade, mitotic activity index, lymph-node status, vascular invasion, and HER2 status) was analyzed. Results: All tumors were of no special type. The mean age of patients was of 65 years. There was no multifocality. Sixty percent of tumors had a high ratio and 40% a low ratio. High ratio tumors were significantly correlated with large size (p=0.02), grade 3 (p=0.045), presence of vascular invasion (p=0.0034) and lymph node metastasis (p=0.0012). No significant association was found with the mitotic activity index and HER2 status. Conclusion: High TSR was related to poor histopathological parameters in EP positive breast carcinomas, contrasting data in triple-negative breast cancer, and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.