EP375 Abdominal radical histerectomy for cervical cancer: recurrence and disease-free survival in a portuguese oncologic center. (1st November 2019)

• Record Type: Journal Article
• Authors: Oliveira, CA; Monteiro, C; Serrano, P
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 4
• Page Start: A255
• Page End: A255
• Publication Date: 2019-11-01
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-ESGO.434
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: Abdominal radical hysterectomy (RAH) with pelvic lymphadenectomy is the standard treatment for patients with early stage cervical cancer, and in our country this is the only approach possible in most oncologic centres. Studies comparing surgical techniques concluded that minimal invasive surgery (MIS) is associated with better short term outcomes with similar oncologic outcomes, and therefore MIS has been used at several centers. Recently, LACC study concluded that MIS in cervical cancer was associated with higher rate of recurrence and lower disease-free survival (DFS). Some authors argued that this results were due to a high rate of DFS reported in the RAH group. We evaluated if the DFS in RAH reported in this study was the reality in our oncologic center. Methodology: We peformed a retrospective study including all cases (n=43) of FIGO stage I–II cervical cancer who underwent RAH in our institution between January 2003 and April 2017. Patient characteristics, post-operative complications, recurrence rate and DFS at 2-years and 5-years follow-up were analyzed. Results: The mean age of the patients was 51 years. Most patients had clinical stage IB1 disease (74%). Rates of adjuvant radiotherapy was 46%, and was administered in high risk patients. The rate of late post-treatment complications was 30%, most of them associated with dual-modality treatment. 5 patients had a recurrence (11.6%), all occurred in the vaginal vault or pelvis. No carcinomatosis or distant metastases were reported. The rate of DFS at 2 years was 93% and 93% of DFS at 5 years in the patients that had at least this time of follow-up. Conclusion: Our findings are consistent with the high DFS rates of LACC trial, suggesting that this is not a DFS rate exclusive of referral oncologic centers. Despite the small sample size, our findings confirm the oncologic safety in the open abdominal technique. Disclosure: Nothing to disclose.