The Evolving Molecular Landscape of High-Grade Gliomas. Issue 5 (September 2021)

• Record Type: Journal Article
• Authors: Pinarbasi, Emile; Pratt, Drew
• Is Part Of: Cancer journal. Volume 27:Issue 5(2021)
• Page Start: 337
• Page End: 343
• Publication Date: 2021-09
• Subjects: Gliomas -- HGG -- methylation -- molecular; Cancer -- Periodicals; 616.994005
• DOI: 10.1097/PPO.0000000000000542
• Languages: English
• ISSNs: 1528-9117

Abstract

Abstract: The classification, diagnosis, and biological understanding of high-grade gliomas has been transformed by an evolving understanding of glioma biology. High-grade gliomas, in particular, have exemplified the impact of molecular alterations in pathology. The discovery of mutations in a key metabolic enzyme (IDH), histone genes (H3-3A), and large-scale chromosome changes (+7/−10, 1p/19q) are examples of specific alterations that now supplant traditional histologic interpretation. Here, we review established and recently defined types of adult and pediatric high-grade gliomas with discussion of key molecular alterations that have been leveraged for subclassification, grading, or prognosis.