Is neuroendocrine differentiation useful to discriminate primary sinonasal intestinal-type adenocarcinomas from metastatic colorectal adenocarcinomas?. Issue 1 (7th October 2014)

• Record Type: Journal Article
• Authors: Projetti, Fabrice; Serrano, Elie; Vergez, Sebastien; Bissainthe, Anne-Charlotte; Delisle, Marie-Bernadette; Uro-Coste, Emmanuelle
• Is Part Of: Journal of clinical pathology. Volume 68:Issue 1(2015)
• Page Start: 79
• Page End: 82
• Publication Date: 2014-10-07
• Subjects: IMMUNOHISTOCHEMISTRY -- HEAD AND NECK CANCER -- Neuroendocrine; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2014-202463
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Primary sinonasal intestinal-type adenocarcinomas (ITAC) are defined on the basis of their morphological similarities to colorectal adenocarcinomas (CRA). Thus, differential diagnosis with sinonasal metastasis of CRA could be a real challenge. Neuroendocrine differentiation has been variably described in several types of adenocarcinomas and notably in ITACs and CRAs. In a series of 25 ITACs and 25 lymph node metastasis of CRAs (nmCRA), we analysed neuroendocrine differentiation by immunohistochemistry with anti-chromogranin A and synaptophysin antibodies. Neuroendocrine differentiation (chromogranin A and/or synaptophysin positivity) was significantly different (p=0.0002) in ITACs (72%) and in nmCRAs (20%). In conclusion, presence of neuroendocrine cells seems more in favour of a sinonasal intestinal-type adenocarcinoma, than metastatic CRA. This immunohistochemical study could be useful in difficult cases and should be an interesting complement in a clinical discussion.