Gastric emptying time of two different quantities of clear fluids in children: A double‐blinded randomized controlled study. Issue 11 (12th August 2021)

• Record Type: Journal Article
• Authors: Taye, Sunny; Mohammed, Sadik; Bhatia, Pradeep; Kumar, Mritunjay; Chhabra, Swati; Kumar, Rakesh; Kumari, Kamlesh
• Is Part Of: Paediatric anaesthesia. Volume 31:Issue 11(2021)
• Page Start: 1187
• Page End: 1193
• Publication Date: 2021-08-12
• Subjects: emptying half‐time -- gastric emptying time -- preoperative fasting -- vomiting; Pediatric anesthesia -- Periodicals; 617.96798
• DOI: 10.1111/pan.14261
• Languages: English
• ISSNs: 1155-5645

Abstract

Abstract: Background: Perioperative pulmonary aspiration risk increases with increased preoperative gastric volume; hence traditionally, healthy children are kept fasted overnight before surgery. Current guidelines recommend 2‐h clear fluids fasting prior to anesthesia. However, emerging evidence favors allowing 3 ml/kg clear fluids up to 1‐h before anesthesia. We compared the gastric volume and gastric emptying time after ingestion of 3 ml/kg and 5 ml/kg of clear fluids. Methods: The present study enrolled 44 children, aged between 6 and 14 years. On the day of surgery, baseline gastric volume was estimated using ultrasound and patients were randomly allocated into two groups of equal number, that is, Group 3 and Group 5 (patients received 3 ml/kg and 5 ml/kg 5% Dextrose respectively). Repeated gastric ultrasound was performed at every 5 min until the gastric volume reached baseline levels. The primary objective of the study was to compare gastric emptying time. Secondary objectives included comparison of antral cross‐sectional area and gastric volume. Results: The demographic profile, preoperative fasting duration for clear fluids, and baseline gastric volume were comparable between groups. In both groups, compared to baseline the antral cross‐sectional area and gastric volume increased significantly following fluid ingestion and then decreased exponentially to reach baseline within 1‐h. The median (IQR) (range) gastric emptying time (minutes) [35.0 (28.8, 40.0) (20.0–45.0) in group 3 and 40.0 (28.8, 45.0) (20.0−50.0) in group 5] and emptying half‐time (minutes) [17.0 (15.7, 21.5) (14.4–24.0) in group 3 and 18.6 (16.0, 22.0) (15.1–23.8) in group 5] were comparable [median difference −5 (95% CI −7.8 to 2.1) and –1.5 (95% CI −2.3 to 1.0), respectively] ( p = .16 and p = .44, respectively). Conclusion: As the gastric volume returned to baseline within 1‐h even after ingesting 5 ml/kg clear fluids, the preoperative fasting time can be reduced to 1‐h and healthy children undergoing elective procedure can be safely allowed to drink up to 5 ml/kg clear fluids.