EP235 The effect of bariatric surgery on breast cancer. (1st November 2019)

• Record Type: Journal Article
• Authors: Vasileiadou, D; Antiochos, K; Litos, M; Skrekas, G
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 4
• Page Start: A190
• Page End: A190
• Publication Date: 2019-11-01
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-ESGO.297
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: It is well known that obesity is associated with an increased risk of cancer. Considering its high prevalence, obesity is an important risk factor for cancer. Obesity is not only associated with new cancer cases but also with more advanced cancer disease and increased cancer mortality. Hormone - related cancers, such as endometrial and breast cancers, have both been associated with obesity. Bariatric surgery is the most effective treatment for achieving weight loss and sustaining normal weight in patients with obesity. Methodology: The present study is a review of literature. Results: Bariatric surgery has been shown to reduce the overall cancer risk in patients with obesity. Regarding breast cancer, several large - scale studies and meta-analyses have shown significant reduction in the risk of breast cancer in women undergoing bariatric surgery, with an odds ratio of 0.25–0.5. Mechanisms that have been proposed as contributors to the increased risk between obesity and breast cancer include estrogen excess through increased aromatase activity in adipose tissue, insulin resistance and increased circulating glucose, that have both shown to be growth factors for cellular proliferation, and obesity-related pro-inflammatory state with higher levels of interleukins, TNF, and adipokines. Conclusion: Bariatric surgery may protect obese patients from breast cancer. Weight loss and bariatric surgery may be suggested to obese women as an additional preventative modality. Disclosure: Nothing to disclose.