Malignant melanoma showing smooth muscle differentiation. Issue 11 (November 1996)

• Record Type: Journal Article
• Authors: Banerjee, S S; Bishop, P W; Nicholson, C M; Eyden, B P
• Is Part Of: Journal of clinical pathology. Volume 49:Issue 11(1996)
• Page Start: 950
• Page End: 951
• Publication Date: 1996-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.49.11.950
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.