EP704 Is SOFA score reliable in a gynecologic oncology setting or is something missing? A retrospective study on predictors and risk factors for bloodstream infections. (1st November 2019)

• Record Type: Journal Article
• Authors: Corrado, G; Franza, L; Costantini, B; Spanu, T; Covino, M; Ojetti, V; Quagliozzi, L; Biscione, A; Taccari, F; Fagotti, A; Tamburrini, E; Scambia, G
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 4
• Page Start: A400
• Page End: A400
• Publication Date: 2019-11-01
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-ESGO.758
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: Study aim was to determine whether sepsis organ failure assessment (SOFA) score is a useful diagnostic tool in patients with an underlying gynecologic malignancy and if other parameters could be used as bloodstream infection predictors. Methodology: Between July 2016 and December 2017, 68 patients accessing the Emergency Ward with an underlying gynecologic malignancy were recruited. Variables concerning underlying disease, invasive procedures, laboratory and SOFA score parameters were analyzed. Patients were divided in 3 groups based on their blood and urine specimens. Risk factors for surgical site infections (SSIs), recent (<30 days) surgery and chemotherapy were studied separately. Results: Parameters included in the SOFA score and SOFA score itself were not significant predictors of bloodstream infection. Patients who had been treated with chemotherapy were at a higher risk of developing bloodstream infection (p=0.04; OR=7.9). In a rough model, C reactive protein (CRP), bilirubin and oxygen saturation (SO2 ) were significantly different between patients with an underlying infection and those who had not. Only CRP maintained its significance in a complex model, with a cutoff of 180 mg/L (linear regression, p=0.03; OR=4). Conclusion: SOFA score does not seem reliable in diagnosing bloodstream infections in patients with an underlying malignancy, but other criteria may help an early diagnosis. Disclosure: Nothing to disclose.