Sources and Fate of the Antiandrogenic Fluorescent Dye 4‐Methyl‐7‐Diethylaminocoumarin in Small River Systems. (24th September 2021)

• Record Type: Journal Article
• Authors: Muschket, Matthias; Brack, Werner; Inostroza, Pedro A.; Beckers, Liza‐Marie; Schulze, Tobias; Krauss, Martin
• Is Part Of: Environmental toxicology and chemistry. Volume 40:Number 11(2021)
• Page Start: 3078
• Page End: 3091
• Publication Date: 2021-09-24
• Subjects: Bioaccumulation -- Endocrine‐disrupting compounds -- Environmental fate -- Environmental partitioning -- Equilibrium partitioning theory; Pollution -- Environmental aspects -- Periodicals; Environmental chemistry -- Periodicals; 615.902
• DOI: 10.1002/etc.5181
• Languages: English
• ISSNs: 0730-7268

Abstract

Abstract: Recently, the potent antiandrogen 4‐methyl‐7‐diethylaminocoumarin (C47) and its potential transformation products 4‐methyl‐7‐ethylaminocoumarin (C47T1) and 4‐methyl‐7‐aminocoumarin (C47T2) were identified as novel environmental contaminants. We assessed for the first time the sources, distribution, and fate of these compounds in aquatic systems using the Holtemme River (Saxony‐Anhalt, Germany), which is a hotspot for these contaminants. To this end, wastewater‐treatment plant (WWTP) influent and effluent samples, surface water samples over 3 years, and the longitudinal profiles in water, sediment, and gammarids were analyzed. From the longitudinal profile of the river stretch, the WWTP of Silstedt was identified as the sole point source for these compounds in the River Holtemme, and exposure concentrations in the low micrograms per liter range could be recorded continuously over 3 years. Analysis of WWTP influent and effluent showed a transformation of approximately half of the C47 into C47T1 and C47T2 but no complete removal. A further attenuation of the three coumarins after discharge into the river could be largely attributed to dilution, while transformation was only approximately 20%, thus suggesting a significant persistence in aquatic systems. Experimentally derived partitioning coefficients between water and sediment organic carbon exceeded those predicted using the OPERA quantitative structure–activity relationship tools and polyparameter linear free‐energy relationships by up to 93‐fold, suggesting cation binding as a significant factor for their sorption behavior. Near‐equilibrium conditions between water and sediment were not observed close to the emitting WWTP but farther downstream in the river. Experimental and predicted bioaccumulation factors for gammarids were closely matching, and the concentrations in field‐sampled gammarids were close to steady state with exposure concentrations in the water phase of the river. Environ Toxicol Chem 2021;40:3078–3091. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.