155 Prognostic value and therapeutic implications of pleural carcinosis and malignant pleural effusion in advanced epithelial ovarian cancer. (13th November 2020)

• Record Type: Journal Article
• Authors: Nasser, S; Fotopoulou, C; Richter, R; Kaulich, J; Braicu, E; Beteta, C; Olschewski, J; Babyeva, A; Sehouli, J
• Is Part Of: International journal of gynecological cancer. Volume 30(2020)Supplement 3
• Page Start: A68
• Page End: A68
• Publication Date: 2020-11-13
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2020-IGCS.134
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: The aim of the study is to demonstrate the prognostic value of pleural carcinosis and effusion in a large cohort of advanced epithelial ovarian cancer(EOC) patients operated within a maximal-effort setting and the hereby associated therapeutic implications. Methods: Overall, 388 EOC patients with confirmed malignant pleural effusion (MPE) and/or carcinosis were retrospectively analysed. Exclusion criteria were non-epithelial ovarian malignancies and presence of other comorbidities associated with pleural effusions. Results: The incidence of the pleural involvement at the time of diagnosis in our institution was 9.4%. The majority of the patients (82.3%) were symptomatic with a poorer performance status due to the pleural effusion/carcinosis. The prognosis after the occurrence of the MPE during the EOC in relapsed cases was poor with 9, 9 months. In the multivariate analysis, the time point of the manifestation of the pleural effusion (primary vs relapse) (p<0.001), platinsensitivity (yes vs no) (p=0.003), performance status (0/1 vs 2/3) (p=0.045) and presence of ascites (yes vs no) (p=0.004) were significant prognostic factors for overall survival (OS). Patients with FIGO stage IVA and IVB who were operated tumor free had longer OS rates. Conclusion: Even in this less favourable patient collective, the otherwise well-established prognostic factors of EOC were associated with a significantly better OS. This suggests that the overall behavioral pattern of the disease has strong similarities in patients with and without pleural effusion/carcinosis and merits an equally high therapeutic effort approach.