Identification and characterization of metamorphic proteins: Current and future perspectives. Issue 10 (16th September 2021)

• Record Type: Journal Article
• Authors: Das, Madhurima; Chen, Nanhao; LiWang, Andy; Wang, Lee‐Ping
• Other Names: LiWang Andy guestEditor.; Porter Lauren L. guestEditor.; Wang Lee‐Ping guestEditor.
• Is Part Of: Biopolymers. Volume 112:Issue 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-16
• Subjects: fold switching -- KaiB -- lymphotactin -- metamorphic protein -- metamorphome; Biopolymers -- Periodicals; Peptides -- Periodicals; Spectrum analysis -- Periodicals; 572.33
• DOI: 10.1002/bip.23473
• Languages: English
• ISSNs: 0006-3525

Abstract

Abstract: Proteins that can reversibly alternate between distinctly different folds under native conditions are described as being metamorphic. The "metamorphome" is the collection of all metamorphic proteins in the proteome, but it remains unknown the extent to which the proteome is populated by this class of proteins. We propose that uncovering the metamorphome will require a synergy of computational screening of protein sequences to identify potential metamorphic behavior and validation through experimental techniques. This perspective discusses computational and experimental approaches that are currently used to predict and characterize metamorphic proteins as well as the need for developing improved methodologies. Since metamorphic proteins act as molecular switches, understanding their properties and behavior could lead to novel applications of these proteins as sensors in biological or environmental contexts. Abstract :