Aggressive pursuit and utilization of non‐ideal donor lungs does not compromise post‐lung transplant survival. Issue 9 (14th July 2021) - Halpern, Samantha E.
Abstract: Background: Organ procurement organizations (OPOs) vary in willingness to pursue and utilize non‐ideal donor lungs; implications of these practices for lung transplant (LTx) recipients remain unclear. We examined associations between OPO‐level behavior toward non‐ideal donors and post‐LTx outcomes. Methods: Adult lung donors and corresponding adult first‐time LTx recipients in the 2008–2019 UNOS registry were included. Non‐ideal donors had any of age > 50, smoking history ≥20 pack‐years, PaO2 /FiO2 ratio ≤350, donation after circulatory death, or increased risk status. OPOs were classified as least, moderately, or most aggressive based on non‐ideal donor pursuit, consent attainment, lung recovery, and transplantation. Post‐transplant outcomes were compared among aggressiveness strata. Results: Of 22, 795 recipients, 6229 (27.3%), 8256 (36.2%), and 8310 (36.5%) received lungs from least, moderately, and most aggressive OPOs, respectively. Moderately aggressive OPOs had the highest recipient rates of pre‐discharge acute rejection, grade 3 primary graft dysfunction, postoperative extracorporeal membrane oxygenation, and longest lengths of stay. After adjustment, moderately and most aggressive OPOs had similar risks of recipient mortality as least aggressive OPOs. Conclusions: The most and least aggressive OPOs achieve similar patient survival and short‐term post‐LTx outcomes. Aggressive pursuit and utilization of non‐ideal donor lungs by less aggressive OPOs would likely expand the donor pool, without compromising recipient outcomes.