Peptide‐Based Inhibitors for SARS‐CoV‐2 and SARS‐CoV. Issue 10 (6th August 2021)

• Record Type: Journal Article
• Authors: Panchal, Disha; Kataria, Jeena; Patel, Kamiya; Crowe, Kaytlyn; Pai, Varun; Azizogli, Abdul‐Rahman; Kadian, Neil; Sanyal, Sreya; Roy, Abhishek; Dodd‐o, Joseph; Acevedo‐Jake, Amanda M.; Kumar, Vivek A.
• Is Part Of: Advanced therapeutics. Volume 4:Issue 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-06
• Subjects: coronavirus -- peptide therapeutics -- SARS‐CoV -- SARS‐CoV‐2 -- SARS‐CoV‐2 mutants; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202100104
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: The COVID‐19 (coronavirus disease) global pandemic, caused by the spread of the SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2) virus, currently has limited treatment options which include vaccines, anti‐virals, and repurposed therapeutics. With their high specificity, tunability, and biocompatibility, small molecules like peptides are positioned to act as key players in combating SARS‐CoV‐2, and can be readily modified to match viral mutation rate. A recent expansion of the understanding of the viral structure and entry mechanisms has led to the proliferation of therapeutic viral entry inhibitors. In this comprehensive review, inhibitors of SARS and SARS‐CoV‐2 are investigated and discussed based on therapeutic design, inhibitory mechanistic approaches, and common targets. Peptide therapeutics are highlighted, which have demonstrated in vitro or in vivo efficacy, discuss advantages of peptide therapeutics, and common strategies in identifying targets for viral inhibition. Abstract : SARS‐CoV‐2 has rapidly spread across the globe, impacting millions. With its rise, the design of peptide inhibitors has expanded swiftly, and in the last 18 months many groups have worked to identify both new viral targets for inhibition and potential therapeutics. Here much of the recent work in the field is covered, and recent computational and experimental data are consolidated.