Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?. Issue 4 (4th August 2011)

• Record Type: Journal Article
• Authors: Kulkarni, Subhash; Becker, Laren; Pasricha, Pankaj Jay
• Is Part Of: Gut. Volume 61:Issue 4(2012)
• Page Start: 613
• Page End: 621
• Publication Date: 2011-08-04
• Subjects: Enteric nervous system -- ENS disorders -- stem cells -- transplantation -- challenges -- enteric nervous system -- enteric neuromuscular disease -- enteric neurones -- neurogastroenterology -- stem cells; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.2010.235614
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Current advances in our understanding of stem and precursor cell biology and in the protocols of stem cell isolation and transplantation have opened up the possibility of transplanting neural stem cells for the treatment of gastrointestinal motility disorders. This review summarises the current status of research in this field, identifies the major gaps in our knowledge and discusses the potential opportunities and hurdles for clinical application.