Research in progress—LungSEARCH: a randomised controlled trial of surveillance for the early detection of lung cancer in a high-risk group. Issue 1 (2nd July 2015)

• Record Type: Journal Article
• Authors: Spiro, Stephen G; Hackshaw, Allan
• Other Names: author non-byline.; Shah Pallav author non-byline.; Novelli Marco author non-byline.; Kocjan Gabrijela author non-byline.; Shaw Penny author non-byline.; Taylor Magali author non-byline.; Padley Simon author non-byline.; Griffiths Chris author non-byline.; Falzon Mary author non-byline.; Plant Paul author non-byline.; Callister Matthew author non-byline.; Peake Mick author non-byline.; Rintoul Robert author non-byline.; George Jeremy author non-byline.; Janes Sam author non-byline.; Keaney Niall author non-byline.; Sridharan Kishore author non-byline.; Dhillon Paul author non-byline.; Warke Timothy author non-byline.; Magee Nicholas author non-byline.; Booton Richard author non-byline.
• Is Part Of: Thorax. Volume 71:Issue 1(2016)
• Page Start: 91
• Page End: 93
• Publication Date: 2015-07-02
• Subjects: Lung Cancer; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2015-207433
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Low-dose CT screening for lung cancer is effective but expensive. Therefore, cheaper or more focused screening strategies may be required. LungSEARCH is a randomised prospective trial of 1568 high-risk individuals (ie, current or former moderate to heavy smokers with mild/moderate COPD) who undergo either annual sputum cytology/cytometry testing or no screening. Those with abnormal sputum then receive annual CT and fluorescent bronchoscopy for the remainder of 5 years, to identify early stage lung cancer. It is hoped that these simple initial tests could identify those requiring expensive CT scans, and the aim is to demonstrate a stage shift towards early stage cancers. Trial registration numbers ISRCTN: ISRCTN80745975, clinicaltrials.gov: NCT00512746 .