IDDF2019-ABS-0161 Application of fentanyl combined with midazolam in diagnosis and treatment of longitudinal endoscopic ultrasonography and observation of sedative effect. (June 2019)

• Record Type: Journal Article
• Authors: Pei, Rong; Yang, Xiujiang; Zhang, Wenming; Chen, Yi; Chen, Ke
• Is Part Of: Gut. Volume 68(2019)Supplement 1
• Page Start: A92
• Page End: A92
• Publication Date: 2019-06
• Subjects: fentanyl -- midazolam -- longitudinal ultrasound endoscopy -- efficacy and safety; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2019-IDDFAbstracts.173
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: To investigate the efficacy and safety of fentanyl combined with midazolam in the diagnosis and treatment of longitudinal endoscopic ultrasonography. Methods: A total of 260 patients undergoing longitudinal endoscopic ultrasonography were selected and randomly divided into observation group and control group with 130 cases in each group. Anxiety and fear patients were given psychological intervention before the operation. The observation group was anesthetized with fentanyl combined with midazolam by intravenous injection, while the control group was given 0.9% sodium chloride solution of equal volume. Heart rate and blood oxygen saturation were observed and compared before, during, at the end of the examination and 20 minutes after the operation. The total time of diagnosis and treatment, sedation depth and adverse reactions were observed and compared between the two groups. Results: HR in the observation group was lower than that before the examination, and HR in the control group was higher than that before the examination. Compared with the observation group at the same time, HR in the control group was higher during and at the end of the examination and the difference was statistically significant (P < 0.05). The incidence of side effects such as nausea, vomiting, cough, physical movement, mucosal hemorrhage, midway termination and operation time of the patients in the observation group were significantly lower than those in the control group, and the sedation effect, patient comfort and satisfaction of the patients were significantly higher than those in the control group, with statistical significance (P < 0.05). Conclusions: Fentanyl combined with midazolam has a good sedative and analgesic effect in the diagnosis and treatment of longitudinal endoscopic ultrasonography and is safe.