Single-cell RNA sequencing for the study of lupus nephritis. Issue 1 (4th June 2019)

• Record Type: Journal Article
• Authors: Der, Evan; Suryawanshi, Hemant; Buyon, Jill; Tuschl, Thomas; Putterman, Chaim
• Is Part Of: Lupus science & medicine. Volume 6:Issue 1(2019)
• Publication Date: 2019-06-04
• Subjects: lupus nephritis -- systemic lupus erythematosus -- inflammation; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1136/lupus-2019-000329
• Languages: English
• ISSNs: 2398-8851

Abstract

Abstract : Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity in cell populations, and the pinpointing of pathological populations contributing to disease. Here we review the development of scRNA-seq technology and the analysis that has evolved with the ever-increasing throughput. Finally, we highlight recent applications of scRNA-seq to understand the molecular pathogenesis of lupus and lupus nephritis.