Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis. Issue 3 (22nd September 2018)

• Record Type: Journal Article
• Authors: Njock, Makon-Sébastien; Guiot, Julien; Henket, Monique A; Nivelles, Olivier; Thiry, Marc; Dequiedt, Franck; Corhay, Jean-Louis; Louis, Renaud E; Struman, Ingrid
• Is Part Of: Thorax. Volume 74:Issue 3(2019)
• Page Start: 309
• Page End: 312
• Publication Date: 2018-09-22
• Subjects: idiopathic pulmonary fibrosis -- interstitial fibrosis; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2018-211897
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity.