P10 Antiphospholipid antibodies associated extra-criteria clinical manifestations should not be ignored. (23rd March 2020)

• Record Type: Journal Article
• Authors: Zhao, Jiuliang; Hu, Chaojun; Huang, Can; Tian, Xinping; Li, Mengtao; Zeng, Xiaofeng
• Is Part Of: Lupus science & medicine. Volume 7(2020)Supplement 1
• Page Start: A33
• Page End: A34
• Publication Date: 2020-03-23
• Subjects: Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1136/lupus-2020-eurolupus.59
• Languages: English
• ISSNs: 2398-8851

Abstract

Abstract : Background: The current Sydney classification criteria do not consider a range of non-thrombotic clinical manifestations that are frequently observed in association with the presence of aPLs, the so-called extra-criteria manifestations. The aim of this study was to retrospectively analysis our single center Antiphospholipid antibodies associated clinical phenotypes, especially the frequency of extra-criteria manifestations. Methods: Data of 731 serum samples from patients of clinical suspected APS in 2018 were enrolled. Data of clinical features, laboratory examination, treatment and prognosis were retrospectively analyzed. Results: A total of 200 patients with APLs were positive (27%), 56 males and 144 females, with an average age of 40.13±17.24 years, 115 cases (57.5%) with ACL positive, 167 cases (83.5%) with anti-β2GPI antibodies positive, 69 cases (34.5%) with LA positive, and 20 cases (10%) turned negative after 12 weeks without any specific therapy. 61(30.5%) patients were fulfilled the 2006 revised Sydney classification criteria for APS. One patient was Catastrophic APS. 27(44.3%) patients with primary APS, 34 (55.6%) were secondary APS, including SLE-APS (20), CTD (9), infection (3), malignancies (2). 119 patients with persistent APLs positive, but were not fulfilled the APS criteria because of without thrombosis or fetal loss. 77 (42.8%) patients were asymptomatic, 42 patients with extra-criteria manifestations. The total frequency of extra-criteria manifestations associated with APLs are 40%. The details are shown in table 1 . Conclusions: The most common extra-criteria manifestations are thrombocytopenia, non-vascular neurological manifestations and valvular heart disease. And they can be the independent clinical feature of APLs without thrombotic events or Pregnancy morbidities.