Interaction of myxobacteria-derived outer membrane vesicles with biofilms: antiadhesive and antibacterial effects. Issue 34 (2nd August 2021)

• Record Type: Journal Article
• Authors: Goes, Adriely; Vidakovic, Lucia; Drescher, Knut; Fuhrmann, Gregor
• Is Part Of: Nanoscale. Volume 13:Issue 34(2021)
• Page Start: 14287
• Page End: 14296
• Publication Date: 2021-08-02
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d1nr02583j
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Outer membrane vesicles derived from myxobacteria can be used as antibiotic drug delivery systems. In this study, we investigate their ability to disrupt and inhibit the growth of bacterial biofilms. Image created with BioRender.com. Abstract : Bacterial biofilms are widespread in nature and in medical settings and display a high tolerance to antibiotics and disinfectants. Extracellular vesicles have been increasingly studied to characterise their origins and assess their potential for use as a versatile drug delivery system; however, it remains unclear whether they also have antibiofilm effects. Outer membrane vesicles are lipid vesicles shed by Gram-negative bacteria and, in the case of myxobacteria, carry natural antimicrobial compounds produced by these microorganisms. In this study, we demonstrate that vesicles derived from the myxobacteria Cystobacter velatus Cbv34 and Cystobacter ferrugineus Cbfe23 are highly effective at inhibiting the formation and disrupting biofilms by different bacterial species.