482 COVID-19 in patients with lung cancer receiving immunotherapy. A report from an spanish academic center. (9th November 2020) - Viñal, David
Abstract : Background: COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared pandemic in March 2020. We know that patients with cancer represent a high risk population. Lung cancer have an already damage lung that may affect the evolution and outcomes of these patients. 1–3 The aim of this study is to report the characteristics and outcomes of patients with lung cancer receiving immunotherapy and SARS-CoV-2 infection. Methods: We retrospectively collected sociodemographic and clinical data from patients with lung cancer and COVID-19 diagnosis who were admitted to La Paz University Hospital (Madrid, Spain) from March 1 to May 7, 2020. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Hazard ratios and corresponding 95% confidence intervals were estimated with the use of Cox proportional-hazards regression models. Results: A total of 29 patients were included. Baseline characteristics are depicted in table 1. Non-small-cell lung cancer (NSCLC) was reported in 93% of the patients and 69% were at advanced stage at the time of COVID-19 diagnosis. Eighty-two percent of the patients were admitted to the hospital and 75% received experimental therapy for COVID-19, including hydroxychloroquine (HCQ) (N=9), HCQ plus azithromycin (N=11) or lopinavir/ritonavir (N=2). A total of 12 patients developed acute distress respiratory syndrome (ADRS) at a median time of 7 days from COVID-19 diagnosis. ADRS was managed with steroids in 75% of the patients. Thirteen (44.8%) deaths were reported, 11 of them were considered to be COVID-19 related. Death occurred at a median time of 8 days. In the univariate analysis, diabetes mellitus, respiratory failure at the time of admission, presence of multilobar infiltrates and SDRA were associated with death.Twenty-two patients were on systemic treatment, of whom 10 patients were receiving immunotherapy alone (N=7) or in combination with chemotherapy (N=3) at the time of COVID-19 diagnosis. No significant association with the development of ADRS (P=0.38) or death (P=0.41) was found between patients on immunotherapy versus other systemic therapies. Overall survival was not reached in the immunotherapy group vs 14 days in patients on other systemic therapies (P=0.25), see figure 1. Conclusions: We found that patients with lung cancer represent an extremely vulnerable population, with a poor prognosis after COVID-19 diagnosis. Treatment with immunotherapy may also be considered a risk factor. Emphasis on prevention and treatment based on evidence-based medicine is crucial in our daily practice. Acknowledgements: This work has not been supported by public grants or financial support. No sources of funding were used to assist in the preparation of this manuscript Ethics Approval: The study was approved by Hospital Universitario La Paz Institution's Ethics Board, approval number PI-4147 References: Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395(10223):507–513. doi:10.1016/S0140-6736(20)30211-7 Giannakoulis VG, Papoutsi E, Siempos II. Effect of Cancer on Clinical Outcomes of Patients With COVID-19: a meta-analysis of patient data. JCO Glob Oncol 2020;6:799–808. doi:10.1200/GO.20.00225 Lee LYW, Cazier JB, Starkey T, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet 2020;395(10241):1919–1926. doi:10.1016/S0140-6736(20)31173-9