PTU-053 Prognostic significance of tumour regression grade in rectal carcinoma – a 5 year study. (8th June 2018)

• Record Type: Journal Article
• Authors: Paulose, Roopa; Menon, Preethi; Bhaskaran, Renjitha; Sundaram, K
• Is Part Of: Gut. Volume 67(2018)Supplement 1
• Page Start: A197
• Page End: A198
• Publication Date: 2018-06-08
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2018-BSGAbstracts.394
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Introduction: Multimodal therapy is the current recommended treatment of choice for rectal cancer. The effects of the neoadjuvant therapy/tumour regression can be assessed histologically in the resection specimen. Methods: This is a 5 year retrospective study at a tertiary centre in South India to assess the prognostic significance of the pathological grading of tumour regression in rectal cancer pre-treated with long course neoadjuvant therapy. 137 patients with rectal adenocarcarcinoma who recieved long course neoadjuvant chemoradiation followed by surgery were analysed and categorised based on the Tumour Regression Grade(TRG) into 2 groups- Group 1(Good response, TRG 0, 1) and Group 2 (Poor response, TRG 2, 3). Other factors (clinical and pathological features like lymphovascular/perineural invasion, discontinuous extramural tumour deposits, resection margin status and pTNM stage of tumour) were also evaluated and all variables along with TRG were correlated with disease progression and 5 year survival. Statistical analysis used: IBM SPSS version 20.0 software. Categorical variables expressed using frequency and percentage and the continuous variables presented using mean and standard deviation. The chi-square test was used for finding prognostic factors. Univariate analyses of survival were carried out by Kaplan-Meier method and the evaluations of differences were performed with Log Rank test. Results: Group 1 showed reduced risk for disease progression (p 0.01) and better mean disease free period and overall survival. Poor tumour regression was associated with lymphovascular and perineural invasion and regional lymph node metastases (p<0.001). Conclusions: Pathological assessment of tumour regression serves as a good predictor for disease outcome and should be assessed in all neoadjuvant treated rectal resection specimens.