Copper-catalyzed redox neutral ketoalkylation of Csp2–H bonds via C–C bond cleavage. Issue 20 (27th August 2021)

• Record Type: Journal Article
• Authors: Chen, He; Guo, Li-Na; Sun, Qing-Xin; Chen, Lei; Tao, Jing-Qi; Gao, Pin
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 20(2021)
• Page Start: 5866
• Page End: 5871
• Publication Date: 2021-08-27
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo00882j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient copper-catalyzed ketoalkylation of Csp 2 –H bonds with cycloalkyl silyl peroxides under mild conditions is presented. A series of Csp 2 –H bonds in quinoxalin-2(1 H )-ones, heteroaromatic N -oxides and quinones were amenable to this protocol. Abstract : An efficient copper-catalyzed ketoalkylation of Csp 2 –H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C–C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1 H )-ones, heteroaromatic N -oxides and quinones with moderate to good yields.