Validation of the Inflammatory Bowel Disease Disability Index in a population-based cohort. Issue 4 (8th December 2015)

• Record Type: Journal Article
• Authors: Gower-Rousseau, Corinne; Sarter, Hélène; Savoye, Guillaume; Tavernier, Noémie; Fumery, Mathurin; Sandborn, William J; Feagan, Brian G; Duhamel, Alain; Guillon-Dellac, Nathalie; Colombel, Jean-Frédéric; Peyrin-Biroulet, Laurent
• Other Names: author non-byline.; Reinisch Walter author non-byline.; Tilg Herbert author non-byline.; Kamm Michael author non-byline.; D'Haens Geert author non-byline.; Louis Edouard author non-byline.; Van Assche Geert author non-byline.; Feagan Brian author non-byline.; Jan Irvine E author non-byline.; Michetti Pierre author non-byline.; Hibi Toshifumi author non-byline.; Schölmerich Jürgen author non-byline.; Schreiber Stefan author non-byline.; Munkholm Pia author non-byline.; Panes Julian author non-byline.; Alarcos Cieza author non-byline.; Colombel Jean-Frédéric author non-byline.; Cosnes Jacques author non-byline.; Lémann Marc author non-byline.; Lewin Maïté author non-byline.; Mary Jean-Yves author non-byline.; Pariente Benjamin author non-byline.; peyrin-Biroulet Laurent author non-byline.; Travis Simon author non-byline.; Chowers Yehuda author non-byline.; Danese Silvio author non-byline.; Vecchi Maurizio author non-byline.; Hommes Daan W. author non-byline.; Oresland Tom author non-byline.; Fletcher Joel author non-byline.; Loftus Edward V author non-byline.; Sandborn Wlliam J. author non-byline.; Sands Bruce E. author non-byline.;
• Is Part Of: Gut. Volume 66:Issue 4(2017)
• Page Start: 588
• Page End: 596
• Publication Date: 2015-12-08
• Subjects: QUALITY OF LIFE -- INFLAMMATORY BOWEL DISEASE; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2015-310151
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: IBDs are chronic destructive disorders that negatively affect the functional status of patients. Recently, the Inflammatory Bowel Disease Disability Index (IBD-DI) was developed according to standard WHO processes. The aims of the current study were to validate the IBD-DI in an independent patient cohort, to develop an index-specific scoring system and to describe the disability status of a well-defined population-based cohort of French patients with IBD. Methods: From February 2012 to March 2014, the IBD-DI questionnaire was administered to a random sample of adult patients with an established diagnosis of IBD issued from a French population-based registry. The IBD-DI consists of 28 items that evaluate the four domains of body functions, activity participation, body structures and environmental factors. Validation included item reduction and data structure, construct validity, internal consistency, interobserver and intraobserver reliability evaluations. Results: 150 patients with Crohn's disease (CD) and 50 patients with UC completed the IBD-DI validation phase. The intraclass correlation coefficient for interobserver reliability was 0.91 and 0.54 for intraobserver reliability. Cronbach's α of internal consistency was 0.86. IBD-DI scores varied from 0 to 100 with a mean of 35.3 (Q1=19.6; Q3=51.8). IBD-DI scores were highly correlated with Inflammatory Bowel Disease Questionnaire (−0.82; p<0.001) and SF-36 (–0.61; p<0.05) scores. Female gender (p<0.001), clinical disease activity (p<0.0001) and disease duration (p=0.02) were associated with higher IBD-DI scores. Conclusions: The IBD-DI has been validated for use in clinical trials and epidemiological studies. The IBD-DI showed high internal consistency, interobserver reliability and construct validity, and a moderate intraobserver reliability. It comprises 14 questions and ranges from 0 to 100. The mean IBD-DI score was 35.3 and was associated with gender, clinical disease activity and disease duration. Further research is needed to confirm the structural validity and to assess the responsiveness of IBD-DI. Trial registration number: 2011-A00877-34