Poly(tannic acid) nanocoating based surface modification for construction of multifunctional composite CeO2NZs to enhance cell proliferation and antioxidative viability of preosteoblasts. Issue 38 (28th September 2021)

• Record Type: Journal Article
• Authors: Yang, Shuoshuo; Ji, Jiale; Luo, Mengwei; Li, Hailing; Gao, Zhonghong
• Is Part Of: Nanoscale. Volume 13:Issue 38(2021)
• Page Start: 16349
• Page End: 16361
• Publication Date: 2021-09-28
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d1nr02799a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : To meet the requirements for anti-OS bone repair, multifunctional composite ceria nanozymes (CeO2 NZs) were constructed by PTA coating modification on the CeO2 NZ surface with pH regulation. Abstract : Ceria (CeO2 ) based materials possess many antioxidant enzyme-like activities and unique properties for bone repair, but their free radical scavenging function is still insufficient. In order to deal with the complex oxidative stress environment in bone repair, multifunctional composite CeO2 nanozymes (CeO2 NZs), featuring multiple antioxidative properties, were constructed via surface modification on CeO2 NZs with nanoscale poly(tannic acid) (PTA) coatings. Moreover, we adjusted pH conditions (ranging from 4 to 9) to effectively control the formation and antioxidative properties of PTA coatings on CeO2 NZ surfaces. Here, the physical properties of this novel inorganic and organic composite antioxidant, such as surface morphology, particle size, crystal structure, surface charge and element composition, were thoroughly characterized. The PTA/CeO2 NZs showed obvious coating morphology under weak acid conditions (pH = 5–6), and the PTA layer at pH = 5 is about 1 nm in thickness. Compared with untreated CeO2 NZs, the PTA/CeO2 NZs showed stronger SOD-like activity and obviously higher free radical scavenging rate (for both ABTS + ˙ and DPPH˙).Notably, this composite antioxidative nanozyme not only exhibited favorable cell proliferation of preosteoblasts (MC3T3-E1) but also provided strong antioxidative property to maintain cell vitality against H2 O2 induced oxidative damage. In particular, this study provides new insights into the designing of surface polyphenolic coatings at the nanoscale, and these multiple antioxidative properties shown by PTA coated CeO2 NZs make them suitable for protecting cells under the oxidative stress environment.