Connexin 43 signalling and cardioprotection. Issue 12 (30th December 2005)

• Record Type: Journal Article
• Authors: Boengler, K; Schulz, R; Heusch, G
• Is Part Of: Heart. Volume 92:Issue 12(2006)
• Page Start: 1724
• Page End: 1727
• Publication Date: 2005-12-30
• Subjects: Cx, connexin -- IP, ischaemic preconditioning -- PKC, protein kinase C -- ROS, reactive oxygen species -- TOM, translocase of the outer membrane; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2005.066878
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial C×43 in protection by IP is reviewed.