Relationship between renal function and the risk of recurrent atrial fibrillation following catheter ablation. Issue 2 (9th November 2010)

• Record Type: Journal Article
• Authors: Tokuda, Michifumi; Yamane, Teiichi; Matsuo, Seiichiro; Ito, Keiichi; Narui, Ryohsuke; Hioki, Mika; Tanigawa, Shin-ichi; Nakane, Tokiko; Yamashita, Seigo; Inada, Keiichi; Shibayama, Kenri; Miyanaga, Satoru; Yoshida, Hiroshi; Miyazaki, Hidekazu; Date, Taro; Yokoo, Takashi; Yoshimura, Michihiro
• Is Part Of: Heart. Volume 97:Issue 2(2011)
• Page Start: 137
• Page End: 142
• Publication Date: 2010-11-09
• Subjects: Atrial fibrillation -- catheter ablation -- recurrence -- renal function -- radiofrequency ablation (RFA); Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.200824
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Background: Although several clinical variables are associated with the recurrence of atrial fibrillation (AF) following catheter ablation, the influence of renal function remains to be determined. Objective: To evaluate the association of renal function with the outcome of the paroxysmal AF ablation. Methods: 224 patients underwent catheter ablation for paroxysmal AF. The relationship between the pre-procedural clinical valuables and ablation outcomes was evaluated. Results: Over the course of 37.4±24.4 months of follow-up of catheter ablation procedures for AF (mean number of procedures 1.33±0.45), 91.1% of patients (204/224) became free from AF without antiarrhythmic drugs. The estimated glomerular filtration rate (eGFR) was lower in patients with recurrent AF than in those without recurrence (66.6±17.5 vs 78.4±16.8 ml/min/1.73 m 2, p=0.003). AF recurred more frequently in patients with low eGFR (<60 ml/min/1.73 m 2 ) than in those with high eGFR (>60 ml/min/1.73 m 2 ; 24.3% vs 6.7%, p=0.006). Among the various clinical factors, low eGFR (p=0.02) and left atrium (LA) dilatation (p=0.002) independently predicted the clinical outcome of ablation in patients with paroxysmal AF. Conclusion: Low eGFR and LA dilatation independently influence the outcome of catheter ablation for paroxysmal AF.