Synthesis of novel unnatural α-amino acids (UAAs) containing 7-hydroxy-2, 2-dimethyl-chroman using isoxazole as a linker. (27th August 2021)

• Record Type: Journal Article
• Authors: Raghavulu, K.; Gudipati, Ramakrishna; Basavaiah, K.; Rumalla, Chidananda Swamy; Yennam, Satyanarayana; Behera, Manoranjan
• Is Part Of: New journal of chemistry. Volume 45:Number 37(2021)
• Page Start: 17143
• Page End: 17148
• Publication Date: 2021-08-27
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj01985f
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient and novel method for the preparation of unnatural α-amino acids (UAAs) containing 7-hydroxy-2, 2-dimethyl-chroman via a 1, 3-di-polar-cyloaddition reaction has been described. Abstract : An efficient and novel method for the preparation of unnatural α-amino acids (UAAs) containing 7-hydroxy-2, 2-dimethyl-chroman via a 1, 3-di-polar-cyloaddition reaction has been described. Using this method, various new ethyl 2-amino-3-(3-(7-hydroxy-2, 2-dimethylchroman-6-yl)isoxazol-5-yl)propanoate derivatives have been prepared where the isoxazole ring is acting as a linker between alanine and chroman moieties. This is the first example of isoxazole-tethered 2, 2-dimethylchroman-amino acid hybrids.