Pharmacokinetics of lidocaine after bilateral ESP block. Issue 1 (31st August 2020)

• Record Type: Journal Article
• Authors: De Cassai, Alessandro; Bonanno, Claudio; Padrini, Roberto; Geraldini, Federico; Boscolo, Annalisa; Navalesi, Paolo; Munari, Marina
• Is Part Of: Regional anesthesia and pain medicine. Volume 46:Issue 1(2021)
• Page Start: 86
• Page End: 89
• Publication Date: 2020-08-31
• Subjects: analgesia -- anesthesia -- local -- pharmacology -- pain management; Conduction anesthesia -- Periodicals; Pain medicine -- Periodicals; 617.964
• DOI: 10.1136/rapm-2020-101718
• Languages: English
• ISSNs: 1098-7339

Abstract

Abstract : Introduction: Erector spinae plane (ESP) block is an emerging interfascial block with a wide range of indications for perioperative analgesia and chronic pain treatment. Recent studies have focused their attention on mechanisms of action of ESP block. However, the pharmacokinetics of drugs injected in ESP is, as of now, uninvestigated. The aim of this brief report is to investigate the pharmacokinetics of lidocaine in a series of 10 patients. Methods: We are reporting a case series of 10 patients undergoing bilateral ESP block for multilevel lumbar spine surgery. ESP was performed with 3.5 mg/kg of lidocaine based on ideal body weight. Lidocaine concentration was dosed at 5, 15, 30 min and at 1, 2 and 3 hours. Results: Tmax was 5 min for all the patients. Cmax ranged from 1.2 to 3.8 mg/L (mean: 2.59 mg/L). AUC0-3 was high (76%, on average) suggesting an almost complete bioavailability. Age had a negative correlation with T½ of lidocaine. Conclusions: Lidocaine pharmacokinetic after ESP block is well-described by a two-compartment model with a rapid and extensive rate of absorption. Nevertheless, its peak concentrations never exceeded the accepted toxicity limit. Elimination half-life was slightly prolonged, probably due to the advanced age of some patients.